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. 2023 Apr 17;220(7):e20221649. doi: 10.1084/jem.20221649

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Figure S3. — Inhibition of SHP1 tyrosine phosphatase activity enhances positive selection of CD2-iCre; Grb2^f/f thymocytes. Gestation day 16 CD2-iCre; Grb2^f/f fetal thymus lobes were cultured in medium alone for 2 d followed by medium alone or medium containing Pervanadate (10 μM), TPI-1 (40 nM), or BSO (4 mM) for 3 d. Thymocytes were harvested and analyzed by FACS (left panels). Shown on right are %CD4 SP thymocytes or %CD4 SP/%DP thymocytes. Error bars indicate SD (T test). All comparisons are to untreated controls. *P < 0.05. Summary results (right panels) are from four to six thymus lobes for each genotype. The genotype of fetal thymi was confirmed by PCR.