Table 1.

Different forms of bergamot tested, models used, effects, and the references.

Different forms of bergamot	Model used	Effects	Reference
Juice	Neuroblastoma cell line HepG2 cells Neuroblastoma cell lines In vivo model for CRC Rats with experimental periodontitis induced by LPS Differentiated human neuroblastoma cells (SH-SY5Y)	Anti-proliferative Pro-apoptotic Inhibits cell growth and adhesion Chemopreventive activity, pro-apoptotic and anti-inflammatory activities Anti-inflammatory activities Reduction in intracellular ROS and NO, antioxidant activity	Delle Monache et al. 2013; Visalli et al. 2014 Ferlazzo et al. 2016 Navarra et al. 2014 Navarra et al. 2020 Gugliandolo et al. 2018; Ferlazzo et al. 2020
Essential oil	CRC cells A mouse xenograft model Caco-2 CRC tumor cell line Carrageenan-induced paw edema in rats Rat acetic acid-colitis model THP-1 leukemic monocytes exposed to LPS	Promoting cell death Reduction of lung metastases Increase in its cytotoxic capacity Reduce the levels of IL-1β, IL-6, TNF-α, nitrite/nitrate PGE2 Anti-inflammatory activities Anti-inflammatory activity	Visalli et al. 2014 Navarra et al. 2014 Marchese et al. 2020 Gandhi et al. 2020 Adakudugu et al. 2020 Maugeri et al. 2019
Polyphenolic fraction	T47D and MCF7, cell lines Mouse splenocytes Cardiac damage induced by DOXO in rats	Non-toxic inhibitor of HMGR and mammosphere formation, inhibition Rho-GDI signaling Antioxidant activity Antioxidant and cardioprotective effects	Fiorillo et al. 2018 Peng et al. 2019 Carresi et al. 2018