Table 2.
HI and MN antibody responses (GMT and GMR) against H5N1 at Day 1 and Day 43 by age group.
| HI |
MN |
|||||
|---|---|---|---|---|---|---|
| GMT Day 1 (95% Cl) | GMT Day 43 (95% Cl) | GMR Day 43/Day 1 (95% Cl) | GMT Day 1 (95% Cl) | GMT Day 43 (95% Cl) | GMR Day 43/Day 1 (95% Cl) | |
| Age 18–64 y | ||||||
| Homologous | n = 478 | n = 451 | n = 451 | n = 69 | ||
| Turkey/2005 | 6.11 (5.78–6.46)a | 250 (208–302)a | 41 (34–49)a | 6.7 (5.62–7.98) | 410 (313–537) | 61 (44–86) |
| Heterologous | n = 69 | n = 69 | ||||
| Anhui/2005 | 5.02 (4.87–5.18) | 11 (6.64–17) | 2.09 (1.29–3.37) | 16 (12–21) | 156 (131–186) | 9.93 (7.47–13) |
| Egypt/2010 | 5.87 (4.51–7.63) | 39 (22–71) | 6.52 (3.62–12) | 15 (11–22) | 522 (398–685) | 34 (23–49) |
| Hubei/2010 | 7.12 (5.01–10) | 56 (31–102) | 7.3 (4.01–13) | 7.2 (6–8.63) | 51 (41–63) | 7.07 (5.56–8.98) |
| Indonesia/2005 | 5.02 (4.87–5.18) | 16 (9.17–28) | 3.12 (1.81–5.39) | 8.79 (7–11) | 114 (89–146) | 13 (9.42–18) |
| Vietnam/1203/2004 | 5.97 (4.41–8.06) | 44 (24–81) | 6.99 (3.84–13) | 5.59 (4.98–6.27) | 27 (21–34) | 4.76 (3.74–6.06) |
| Age ≥65 y | ||||||
| Homologous | n = 693 | n = 673 | n = 673 | n = 35 | ||
| Turkey/2005 | 8.29 (7.57–9.08)a | 129 (110–152)a | 16 (13–19)a | 7.49 (5.87–9.56) | 169 (107–268) | 23 (13–39) |
| Heterologous | n = 35 | n = 35 | ||||
| Anhui/2005 | 5 (5–5) | 8.53 (5.92–12) | 1.71 (1.18–2.46) | 28 (20–41) | 128 (99–165) | 4.52 (2.93–6.97) |
| Egypt/2010 | 6.86 (4.94–9.53) | 27 (15–47) | 3.88 (2.27–6.64) | 25 (15–41) | 303 (206–447) | 12 (6.69–22) |
| Hubei/2010 | 7.43 (5.28–10) | 36 (20–64) | 4.83 (2.8–8.32) | 11 (7.98–16) | 42 (31–58) | 3.75 (2.6–5.4) |
| Indonesia/2005 | 5 (5–5) | 12 (8.02–18) | 2.39 (1.6–3.56) | 18 (13–27) | 87 (63–120) | 4.77 (3.1–7.34) |
| Vietnam/1203/2004 | 7.81 (5.24–12) | 34 (19–63) | 4.41 (2.57–7.57) | 7.32 (5.39–9.95) | 27 (19–39) | 3.68 (2.62–5.17) |
Abbreviations: CI, confidence interval; GMR, geometric mean ratio; GMT, geometric mean titer; HI, hemagglutination inhibition; MN, microneutralization.
a97.5% CI.