Table 3.

Determination of 90% thresholds for the approved mAbs within the set of 137 mAbs with experimental data.

Assay	Approved – 2017	Number – 2017	Approved – 2022	Number – 2022
Fe2+ FVIII	6.68 ± 0.67	34	6.67 ± 0.55	50
Fe2+ C3	4.67 ± 1.03	34	4.69 ± 0.62	50
Fe2+ LysM	8.28 ± 0.72	34	8.27 ± 0.49	50
Heme FVIII	6.06 ± 0.79	32	5.87 ± 0.72	48
Heme C3	7.40 ± 0.88	32	7.36 ± 0.78	48
Heme LysM	10.84 ± 2.14	32	10.10 ± 1.36	48
SGAC-SINS	370 ± 136	48	330 ± 128	64
HIC	11.63 ± 0.41	48	11.53 ± 0.27	64
SMAC	12.82 ± 1.20	48	12.62 ± 1.34	64
Tm	64.9 ± 0.93	48	64.2 ± 0.81	64
AS	0.08 ± 0.03	48	0.09 ± 0.04	64
ELISA	1.88 ± 1.03	48	2.06 ± 1.00	64
BVP	4.28 ± 2.22	48	5.30 ± 1.92	64
DNP	0.61 ± 0.25	32	1.24 ± 0.57	48
PSR	0.26 ± 0.06	48	0.31 ± 0.05	64
CIC	10.09 ± 0.46	48	10.09 ± 0.39	64
ACSINS	11.78 ± 6.23	48	13.84 ± 4.8	64
CSI	0.01 ± 0.02	48	0.02 ± 0.02	64
FcRn Rel RT	1.04 ± 0.14	44	1.18 ± 0.11	62
Hep RT	0.81 ± 0.06	44	0.84 ± 0.05	60
Heme	6.66 ± 1.89	32	10.73 ± 3.50	48
FA	2.90 ± 1.20	32	3.52 ± 1.46	48