Table 2.
Association of time-weighted average depressive symptoms and brain age at midlife among 649 CARDIA participants.
| TWA Depressive symptoms | β-coefficient (95 % CI) Brain age | ||
|---|---|---|---|
| Model 1a | Model 2b | Model 3c | |
| Per 1-point increment | 0.26 (0.14 to 0.38) | 0.26 (0.13 to 0.39) | 0.19 (0.05 to 0.33) |
| Per 5-point increment | 1.14 (0.57 to 1.71) | 1.05 (0.42 to 1.67) | 0.65 (−0.01 to 1.31) |
CARDIA, Coronary Artery Risk Development in Young Adults; CI, confidence interval.
a
Adjusted for chronological age, sex, education, race, intracranial volume, and scanning site.
b
Additionally adjusted for anti-depressive medication use.
c
Additionally adjusted for income, alcohol consumption, smoking, BMI, diabetes, and physical exercise.