TABLE 4.

Association of sex steroid hormone concentrations with high ALT concentrations (>40 U/L) in men, NHANES III

		Model 1a		Model 2		Model 3		Model 4
Hormone	Quartilesb	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
Total testosterone	1	1		1		1		1
	2	0.70	[0.21,2.29]	0.80	[0.24,2.62]	1.02	[0.30,3.51]	0.98	[0.29,3.34]
	3	0.38	[0.11,1.32]	0.35	[0.12,1.04]	0.63	[0.18,2.16]	0.55	[0.13,2.30]
	4	0.48	[0.07,3.13]	0.40	[0.05,3.00]	0.93	[0.09,9.53]	0.65	[0.08,5.04]
	P-Trend		.24		.18		.83		.50
Free testosterone	1	1		1		1		1
	2	0.43	[0.12,1.59]	0.40	[0.10,1.50]	0.40	[0.09,1.72]	0.43	[0.10,1.86]
	3	0.28	[0.05,1.69]	0.29	[0.05,1.69]	0.38	[0.06,2.18]	0.47	[0.08,2.88]
	4	0.69	[0.19,2.56]	0.49	[0.12,2.02]	0.82	[0.22,3.08]	1.16	[0.22,6.04]
	P-Trend		.48		.29		.76		.84
Total estradiol	1	1		1		1		1
	2	0.69	[0.27,1.78]	0.60	[0.21,1.69]	0.60	[0.21,1.74]	0.64	[0.21,1.95]
	3	0.79	[0.19,3.34]	0.67	[0.15,3.04]	0.49	[0.12,2.05]	0.49	[0.13,1.83]
	4	1.25	[0.49,3.20]	0.83	[0.29,2.41]	0.76	[0.27,2.11]	0.87	[0.36,2.12]
	P-Trend		.62		.81		.54		.61
Free estradiol	1	1		1		1		1
	2	1.12	[0.37,3.40]	0.94	[0.30,2.92]	0.85	[0.27,2.60]	0.88	[0.30,2.59]
	3	0.80	[0.19,3.38]	0.73	[0.20,2.74]	0.50	[0.14,1.82]	0.48	[0.16,1.49]
	4	1.93	[0.64,5.84]	1.31	[0.39,4.34]	0.79	[0.33,1.89]	0.60	[0.17,2.17]
	P-Trend		.31		.74		.30		.23
SHBG	1	1		1		1		1
	2	0.20	[0.04,0.98]	0.22	[0.04,1.25]	0.33	[0.06,1.88]	0.36	[0.07,1.91]
	3	0.83	[0.26,2.62]	0.90	[0.30,2.69]	1.42	[0.43,4.68]	1.53	[0.59,3.99]
	4	0.61	[0.13,2.90]	0.79	[0.17,3.76]	1.86	[0.27,12.86]	2.43	[0.48,12.21]
	P-Trend		.98		.78		.29		.13
AAG	1	1		1		1
	2	0.53	[0.13,2.12]	0.55	[0.14,2.27]	0.55	[0.12,2.45]	—
	3	1.34	[0.40,4.45]	1.64	[0.46,5.78]	1.23	[0.38,3.97]
	4	1.26	[0.41,3.84]	1.34	[0.40,4.51]	1.41	[0.37,5.41]
	P-Trend		.39		.35		.41

Abbreviations: AAG, androstanediol glucuronide; SHBG, sex hormone-binding globulin.

^aModel 1 adjusted for age and race.

Model 2 additionally adjusted for smoking, alcohol and physical activity. Model 3 additionally adjusted for waist circumference.

Model 4 as model 3, but mutual adjustment for hormones.

^bSee Table 2 for hormone concentrations per quartile.