Table 3.
Macroscopic patterns of WMI
| Number with pattern | Additional features | Intact white matter area (mm2) |
Ventricle area (mm2) | Cystic lesion area (mm2) |
|---|---|---|---|---|
| Control outcomes | ||||
| Control 10 foetuses |
- | 125.3 ± 6.3 | 46.4 ± 3.1 | - |
| White matter atrophy and ventriculomegaly | ||||
| UCO-vehicle 4 foetuses |
One developed focal unilateral lesions in the temporal lobe One developed focal bilateral cystic lesions in the temporal lobe and the second parasagittal gyrus of the parietal lobe |
77.3 ± 7.5 | 86.3 ± 6.6 | 1.1 ± 0.8 |
| UCO-Etanercept 2 foetuses |
Two developed focal unilateral cystic lesions in the temporal lobe contralateral to the site of intracerebroventricular infusion | 101.2 ± 14.9 | 89.5 ± 2.7 | 5.6 ± 0.5 |
| Temporal lobe cystic lesions | ||||
| UCO-vehicle 3 foetuses |
Bilateral lesions Two developed extensive lesions, one developed focal lesions |
101.0 ± 12.2 | 53.1 ± 3.4 | 17.9 ± 11.7 |
| UCO-Etanercept 2 foetuses |
Unilateral focal lesions contralateral to the site of intracerebroventricular infusion | 103.7 ± 7.6 | 66.2 ± 5.2 | 2.2 ± 1.6 |
| No overt macroscopic features | ||||
| UCO-vehicle 2 foetuses |
Microscopic diffuse WMI present | 126.2 ± 20.3 | 60.1 ± 5.7 | - |
| UCO-Etanercept 5 foetuses |
Microscopic diffuse WMI present | 123.7 ± 7.9 | 67.5 ± 12.9 | - |
Foetuses were assigned to subgroups based on their primary pattern of macroscopic injury, although overlap between subgroups were observed. No statistical analysis has been performed due to low numbers in each subgroup. Control outcomes are provided for reference. Data are mean ± SEM.