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. 2022 Oct 22;17(4):513–523. doi: 10.1093/ecco-jcc/jjac161

Figure 2.

Figure 2

Estimated relationship between total Mayo score, the four individual Mayo subscores, the modified Mayo score, and the partial Mayo score as a continuous anchor and the four WPAI-UC components; PGA, Physician Global Assessment; WPAI-UC, Work Productivity and Activity Impairment-Ulcerative Colitis. Data from OCTAVE Induction 1 and 2 and OCTAVE Sustain; all treatment groups from each Phase 3 study were pooled for analysis. WPAI-UC component scores are expressed as percentages, with a higher percentage indicating greater impairment and less productivity. The total Mayo score ranges from 0 to 12 points and each subscore ranges from 0 to 3 points; higher scores indicate more severe disease activity for both total and individual subscores. The modified Mayo score ranges from 0 to 9 points and is the sum of stool frequency, rectal bleeding, and endoscopic subscores, with higher scores indicating more severe disease. The partial Mayo score ranges from 0 to 9 points and is the sum of stool frequency, rectal bleeding, and PGA subscores, with higher scores indicating more severe disease.