Table 1.

Mean percentage point [95% CI] change in WPAI-UC components associated with 1-point or 3-point changes in the total Mayo score, Mayo subscores, modified Mayo score, and partial Mayo score [main model with Mayo score as a continuous anchor].

WPAI-UC component [percentage points]
	Absenteeism	Presenteeism	Work productivity loss	Activity impairment
Total Mayo score
3 points	5.3 [4.6–6.1]	14.7 [13.9–15.6]	13.6 [12.5–14.7]	16.4 [15.7–17.0]
Mayo stool frequency subscore
1 point	4.5 [3.8–5.2]	13.3 [12.4–14.1]	11.7 [10.5–12.8]	14.8 [14.1–15.5]
Mayo rectal bleeding subscore
1 point	7.3 [6.3–8.4]	16.4 [15.2–17.5]	14.5 [13.2–15.9]	17.9 [17.1–18.8]
Mayo endoscopic subscore
1 point	2.8 [2.1–3.5]	9.7 [8.7–10.7]	9.0 [7.5–10.5]	11.1 [10.2–12.0]
Mayo PGA subscore
1 point	5.5 [4.7–6.3]	15.0 [14.1–16.0]	14.3 [13.0–15.6]	16.5 [15.8–17.3]
Modified Mayo score
3 points	6.9 [5.9–7.9]	19.2 [18.0–20.3]	17.5 [15.9–19.0]	21.3 [20.4–22.2]
Partial Mayo score
3 points	7.4 [6.4–8.3]	19.2 [18.2–20.2]	17.6 [16.2–19.0]	21.1 [20.3–21.9]

Data from OCTAVE Induction 1 and 2 and OCTAVE Sustain; all treatment groups from each Phase 3 study were pooled for analysis. WPAI-UC component scores are expressed as percentages, with a higher percentage indicating greater impairment and less productivity. The total Mayo score ranges from 0 to 12 points and each subscore ranges from 0 to 3 points; higher scores indicate more severe disease activity for both total and individual subscores. The modified Mayo score ranges from 0 to 9 points and is the sum of stool frequency, rectal bleeding, and endoscopic subscores, with higher scores indicating more severe disease. The partial Mayo score ranges from 0 to 9 points and is the sum of stool frequency, rectal bleeding, and PGA subscores, with higher scores indicating more severe disease.

CI, confidence interval; PGA, Physician Global Assessment; WPAI-UC, Work Productivity and Activity Impairment-Ulcerative Colitis.