Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 19;9(16):eadf4888. doi: 10.1126/sciadv.adf4888

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 4. — In M2, the distribution areas of GFP⁺ cells in the caudate nucleus [A, low magnification; D, higher magnification taken from the site specified by the arrow in (A)] and the putamen [C, low magnification; E, higher magnification taken from the site specified by the arrow in (C)] overlap the regions of Gd extravasation observed immediately after sonication (arrows in B). Similarly, GFP⁺ cells in the midbrain [H, low magnification; J, higher magnification taken from the site specified by the arrows in (H)] are distributed within the hyperintense BBB-opened area [arrow in (G)]. The same region on the contralateral side served as a negative control showing no hyperintense signal (G) or GFP expression (F and I, low and higher magnification, respectively). Number of GFP⁺ cells in the BBB-opened regions (LIFU⁺) and their contralateral non-opened regions (LIFU⁻) in the caudate nucleus (K), putamen (L), and midbrain (M) of M2 and in the thalamus of M1 (with NAbs) (N). Cd, caudate nucleus; Put, putamen; SN, substantia nigra; STN, subthalamic nucleus. Scale bars, 1 mm (A, C, F, and H) and 50 μm (D, E, I, and J).