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. 2022 Oct 13;13:1008976. doi: 10.3389/fphar.2022.1008976

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Copyright © 2022 Bouwman, Verhaegh and van de Stolpe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnosis of IBD. Datasets indicated on top of figure (A–D). STP activity analysis of intestinal mucosa samples for diagnosis of IBD. Mucosa samples from healthy control individuals and pre-treatment mucosa samples from IBD patients. For details, see Methods. Signal transduction pathway (STP) activity scores (PAS) are shown for the androgen receptor (AR), MAPK, NFκB, TGFβ (TGFbeta), JAK-STAT1/2, JAK-STAT3, and Wnt STPs. PAS on Y-axis on a log2 odds scale. Two sided Mann-Whitney-Wilcoxon statistical tests were performed; p-values are indicated in the figures as *p < 0.05, ***p < 0.001, ****p < 0.0001, ns: not significant.