OS subgroup analyses in the all randomly assigned population. aStratified HR, 0.95. bPer interactive response technology. cStratified HR, 0.82. dStratified HR, 0.78. CPS, combined positive score; ECOG PS, Eastern Cooperative Oncology Group performance status; EXTREME, cetuximab plus cisplatin/carboplatin plus fluorouracil ≤ six cycles, then cetuximab maintenance; HR, hazard ratio; OPC, oropharyngeal cancer; OS, overall survival; PD-L1, programmed death-ligand 1.