TABLE 1.

Properties of Basal Insulins (18)

Product	Onset of Action, hours	Median Time to Reach Peak Serum Concentration, hours	Recommended Injection Timing	Duration of Action at Steady State, hours
NPH	2	4*	One to three times daily	12
Detemir	1–2	6–8	Once daily in the evening or twice daily in the morning and evening	<24
Glargine U100	1–2	8–12	Same time of day	24
Insulin degludec	1	9	Any time of day†	>42
Glargine U300	≤6	12–16	Same time of day‡	<36

^*Mean value reported.

^†With a minimum of 8 hours and a maximum of 40 hours between consecutive doses.

^‡±3 hours.