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. 2023 Mar 29;616(7957):590–597. doi: 10.1038/s41586-023-05832-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, A close-up view of Interaction Patch I in the GSDMB-IpaH7.8 complex. GSDMB is shown as a ribbon diagram. Two negatively charged residues are shown as sticks. IpaH7.8 is shown as electrostatic potentials. The distance between the two small basic pockets formed by R186 and H209 and the surrounding residues in IpaH7.8 is labeled. b, Sequence alignment of the LRR domains of Shigella IpaHs. Secondary structural elements are indicated above the sequence. Universally conserved residues are marked with red shade, and partially conserved residues are colored red. Residues involved in Interface Patch II and I are indicated by red dots and green triangles, respectively. c, Immunoblots of 293T cells co-transfected with FLAG-tagged GSDMB and HA-IpaH7.8 (WT or indicated mutants). Results representative of 3 independent experiments.