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. 2023 Mar 16;29(4):917–926. doi: 10.1038/s41591-023-02255-1

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Plots show the q-values (x-axes, indicating the false discovery rate) determined by GISTIC2.0 with respect to significant lost (blue) and gained (red) genomic regions among the human chromosomes 1 to 22 (hg19) in DNA methylation classes ‘infantile hemispheric glioma’ (a), ‘pleomorphic xanthoastrocytoma’ (b), ‘embryonal tumor with multilayered rosettes’ (ETMR, c), ‘low-grade glioma, MYB/MYBL1-altered’ (d), ‘high-grade glioma, MYCN’ (e), and ‘high-grade glioma, pediatric RTK’ (f). Numbers in brackets indicate sample size for each class. Green lines indicate the significance threshold of q-value < 0.25. The cytobands of significantly altered regions are denoted on the y-axes. See Supplementary Table 2 for a detailed overview of significantly amplified/deleted regions across all DNA methylation classes.