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. 2023 Apr 17;29(4):950–962. doi: 10.1038/s41591-023-02268-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — We used precomputed functional weights from 22 publicly available gene expression reference panels from brain (GTEx v7, CommonMind Consortium (CMC)), peripheral nerve tissues (GTEx v7), heart and arteries (GTEx v7), and blood (Netherlands Twin Registry (NTR) and Young Finns Study (YFS)). Transcriptome-wide significant genes (eGenes) and the corresponding eQTLs were determined using Bonferroni correction, based on the average number of features (4,235 genes) tested across all tissues and correcting for the three independent PVS locations (P < 3.93 × 10⁻⁶). *Significant result in the TWAS and conditional analyses; **significant result in the TWAS and conditional analyses, and with a COLOC PP4 > 0.75; eGenes for loci identified in the GWAS (^†), gene-based test (^‡) or both GWAS and gene-based test (^§).