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. 2023 Apr 12;616(7957):495–503. doi: 10.1038/s41586-023-05868-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 11 — The beads were repeatedly implanted into the anterior part of the right pectoral fin every two weeks (the total is three times) from stage 29. Some beads were retained until stage 31 (blue dots), while others fell during the treatment The embryos with the ROCK-inhibitor beads exhibited fusion, loss, or disorganized fin ray patterning (arrows, 6/9 for 100 μM and 6/10 for 1 mM). Note that abnormal fin ray patterning was never observed in control animals, indicating that the effects not directly associated with a bead in treated embryos were likely derived from the loss of the bead during the treatment. N = 9 for DMSO, 9 for 100 μM inhibitor, and 10 for 1 mM inhibitor beads. The scale bar is 2 mm.