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. 2023 Apr 12;616(7957):563–573. doi: 10.1038/s41586-023-05771-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 11 — a, Correlation of ERVK-7 expression with Danaher geneset scores for immune cells denoted in TRACERx LUAD patients (n = 167). Correlation co-efficient and p values were calculated using linear regression. b, Representative staining intensities for HERV-K(HML-2) envelope glycoprotein in TRACERx LUAD tumour microarray sections (scale bars 500µm; inset scale bars 50 µm). c, Correlation of ERVK-7 expression with global methylation (n = 311 patients) or SOX2 expression in FPKM-UQ (Fragments Per Kilobase of transcript per Million mapped reads upper quartile) (n = 407 patients) in TCGA LUAD samples. Symbols represent individual patients and R and p values were calculated using linear regression. d, Correlation of ERVK-7 expression with ploidy-adjusted ERVK-7 proviral copy numbers in tumour regions (n = 158 patients, 393 regions) from TRACERx LUAD patients (left) or with the average copy number of the ERVK-7 genomic location in TCGA LUAD patients (n = 407 patients) (right). Symbols represent individual regions for TRACERx LUAD and individual patients for TCGA LUAD samples, and R and p values were calculated using linear regression. e, Heatmap of expression of envelope codogenic HERVs in SMC LUAD samples. f, Correlation of ERVK-7 expression with CD8⁺ T cell scores in SMC LUAD samples. Symbols represent individual patients and R and p values were calculated using linear regression.

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