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. 2023 Apr 12;616(7957):525–533. doi: 10.1038/s41586-023-05783-5

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© The Author(s) 2023, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a. CONSORT diagram for the assembly of the TRACERx 421 cohort. 567 patients were recruited to the TRACERx study, 109 of whom were excluded due to subsequent changes to their clinical status, most commonly due to reclassification of histology at surgery. A further 37 patients were excluded due to sample quality control after whole exome sequencing, either due to sample purity or artefact signature contamination. b. A summary of samples removed during quality control. c. Summary of major histologies across 432 genomically analysed tumours.