Fig. 1. Sample distribution and mutational overview in the paired primary metastasis TRACERx 421 cohort.

a, The distribution of metastatic samples by anatomical location; n indicates number of samples used in analyses. b, The total number of mutations and putative driver mutations detected per case (grey bars) and the proportion of these mutations that are unique to the primary tumour (green) or metastasis (dark purple), or shared between primary and metastasis (light purple) per case. The top 20 most frequently mutated cancer genes and their presence/absence in the primary and metastatic samples, including instances of two driver mutations in the same gene, are also shown. The histology, number of primary and metastatic samples sequenced, and adjuvant therapy status is illustrated. No., number; prop., proportion; LN, lymph node.