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. 2023 Apr 12;616(7957):534–542. doi: 10.1038/s41586-023-05729-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a. Across-genome GISTIC2.0 scores are plotted for amplifications and deletions for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Annotated cytobands contain genes overlapping loci with significant G-scores in the metastasis cohort and that have a GISTIC2.0 score difference (GSD) >0 between unpaired metastases and non-metastasizing tumours. b. Individual chromosome plots highlighting genes overlapping significant loci in the metastasis cohort with GSD > 0 that were detected in the unpaired analysis performed in a. c. Across-genome GISTIC2.0 scores are plotted for amplifications and deletions for LUAD and LUSC separating primary LN/satellite lesions and recurrence/progression samples. d. Individual plot highlighting GSD between primary LN/satellite lesions, recurrence/progression samples and non-metastatic primary regions on chromosome 6 encompassing HIST1H3B. The locus is significantly amplified in the primary LN/satellite lesions (GSD = 1.90, q = 1.30e-7). e. Across genome plot showing the frequency of parallel gains/amplification events in red, and frequency of parallel loss/LOH events in blue. The top and bottom panels show the parallel evolution between primary regions harbouring the seeding clone and their paired metastases in LUAD and LUSC respectively; Amp, amplification; Del, deletion; Chr, chromosome; Mb, megabase.