Extended Data Table 3.

Clinical Associations with timing and modes of metastatic divergence

Age, smoking status, histology, disease stage, pleural and lymphovascular invasion, resection margin, presence of pre-operative circulating tumour DNA (ctDNA) and location of disease recurrence were explored. Early divergence was associated with being a smoker, and polyclonal dissemination was associated with extrathoracic disease recurrence. All significant (p < 0.05) results are shown in red with corresponding statistical tests used. All tests performed were two-sided.