Fig. 6.

Scl-Ab restored and further increased cortical bone volume and improved microarchitecture and extrinsic and intrinsic bone properties in both control and diabetic mice. Micro-CT analysis of femur bone microarchitecture and 3-point bending analysis of bone strength after (t4) treatment with Scl-Ab. a Cortical bone area/tissue area (BA/TA), thickness (Ct.Th) and porosity and representative images. b Bone area (BA), medullary area (MA), total area (TA) and polar moment of inertia (pMOI). c Bone biomechanical properties (stiffness, ultimate load, and energy to ultimate load) and d bone material properties (ultimate stress and toughness). For all analyses, n = 10–12 mice per group. Data are presented as box & whisker plot where each dot represents a mouse. ^P < 0.05 versus control LFD mice and *P < 0.05 versus respective vehicle-treated mice by two-way ANOVA with post hoc Bonferroni’s correction for multiple comparisons