Fig. 7.

Scl-Ab increased bone formation, inhibited bone resorption and reversed the impaired osteoblast function in diabetic mice. a P1NP, CTX, TRAP 5b measure after treatment with Scl-Ab in C and DM mice. b Dynamic bone histomorphometric analysis of mineralized surface/bone surface (MS/BS), mineral apposition rate (MAR) and bone formation rate (BFR) at the periosteal surface of the cross-section of the femoral mid-diaphysis after treatment with Scl-Ab in control and DM mice and representative images. c Surface covered by osteoclasts (OcS/BS). For all analyses, n = 10–12 mice per group. Data are presented as box & whisker plot where each dot represents a mouse. ^P < 0.05 versus control LFD mice and *P < 0.05 versus respective vehicle-treated mice by two-way ANOVA with post hoc Bonferroni’s correction for multiple comparisons