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. 2023 Apr 19;14:2229. doi: 10.1038/s41467-023-37691-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Comparison of 14 genes and RNAi control. n = 60 nephrocytes from 3 biologically independent Drosophila (20 nephrocytes per Drosophila). Drosophila genes are followed by human homologs and association indicator from tissue-phenotype analyses: colocalization (RCP ≥ 0.5) and PTWAS associations (FDR ≤ 0.05), including direction of effect. Bar plots indicate mean and standard deviation (SD) of fluorescence of nephrocytes. Significant differences (two-sided t-test) between the gene and control are indicated (*P ≤ 0.001). Exact P values are in Supplementary Data 10. B Fluorescence microscopy images for representative nephrocytes for each Drosophila gene. Left panel: MHC-ANF-RFP assay. Right panel: 10kD Dextran; Hand-GFP nephrocyte nucleus. The scale bar is 20 µm, and it is the same scale for all the panels in this figure.