Table 4.
Diagnostic test characteristic of TET3, FIB-4 index and multivariable model in detecting liver fibrosis and cirrhosis.
| Model | Fibrosis | Cirrhosis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AUROC(95%CI) | P value | Cut-point | NPV | PPV | AUROC(95%CI) | Cut-point | P value | NPV | PPV | |
| TET3(ng/mL) | 0.863(0.804–0.909) | < 0.0001 | 194.41 | 71.80 | 98.60 | 0.916(0.860–0.955) | 201.62 | < 0.0001 | 87.90 | 100 |
| FIB-4 index | 0.813(0.749–0.867) | < 0.0001 | 1.19 | 66.00 | 86.80 | 0.957(0.911–0.983) | 1.84 | < 0.0001 | 90.20 | 91.40 |
| TET3 + FIB-4 index | 0.943(0.899- 0.972) | < 0.0001 | 0.44 | 83.10 | 93.50 | 0.990(0.958–0.999) | 0.52 | < 0.0001 | 96.40 | 100 |
NPV: Cut-point was derived from the Youden’s index, NPV: Negative predictive value, PPV: Positive predictive value.