TABLE 1.
Sample characteristics for exposures and outcomes in the Mendelian randomization analysis. BMI, body mass index; GIANT, Genetic Investigation of Anthropometric Traits; MAGIC, Meta-Analyses of Glucose and Insulin-related traits Consortium; MVP, Million Veteran Program; PGC, Psychiatric Genomics Consortium; SD, standard deviation; WHR, waist-hip ratio.
| Trait | Sample size | References | Consortium | Population | Units |
|---|---|---|---|---|---|
| Schizophrenia | 53,386 cases and 77,258 controls | Trubetskoy et al. (2022) | PGC | European | Log odds |
| BMI | 322,154 | Locke et al. (2015) | GIANT | European | SD (kg/m2) |
| WHR | 21,244 | Shungin et al. (2015) | GIANT | European | SD |
| Blood lipids | 215,551 | Klarin et al. (2018) | MVP | European | SD (mg/dl) |
| Fasting glucose | 200,622 | Chen et al. (2021b) | MAGIC | European | mmol/l |
| Fasting insulin | 151,013 | Chen et al. (2021b) | MAGIC | European | pmol/l |
| Hba1c | 46,368 | Soranzo et al. (2010) | MAGIC | European | % |
| Systolic blood pressure | 757,601 | Evangelou et al. (2018b) | International Consortium of Blood Pressure | European | mmHg |
| Diastolic blood pressure | 757,601 | Evangelou et al. (2018b) | International Consortium of Blood Pressure | European | mmHg |