Figure 5.

Inhibiting inhibitory hippocampal output to the MS increases locomotion. (A) Optogenetic inhibition of the hippocampal inhibitory inputs to the MS by light delivered into the MS. An inhibitory opsin, Jaws, was expressed in the hippocampal GABAergic neurons with AAVs. (B) Red light delivered to the MS increased mouse locomotion measured by maximum speed and accumulative head turn angles in the open field. (Two-tailed paired t-test, *p < 0.05) (Dlx-Jaws, n = 13 mice). The red bars indicate the delivery of optostimulation. (C) No change in maximum speed (left) or accumulative head turn angles (right) occurred when the optical stimulation was not delivered (Left: Two-tailed paired t-test, p = 0.77; Right: Two-tailed paired t-test, p = 0.71) (Dlx-Jaws, n = 13 mice).