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. 2023 Apr 6;15:1042858. doi: 10.3389/fnsyn.2023.1042858

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Copyright © 2023 Chen, Arano, Guo, Saleem, Li and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of cortex-projecting hippocampal interneurons does not change locomotor activity. (A) Expression of EGFP in NDNF-positive interneurons in NDNF-Cre mice by injecting AAV-Dlx-DIO-EGFP into the hippocampus. (B) NDNF-positive interneurons in the hippocampus project to the RSP but not MS. (C) Expression of hM3Dq in NDNF-positive interneurons in the hippocampus (left). Pharmacogenetic activation of NDNF-positive interneurons with clozapine did not alter the distance traveled or time spent in the center of the open field (distance traveled: two-tailed t-test, p = 0.58; time in the center: two-tailed t-test, p = 0.53; data are represented as mean ± SEM; n = 6 mice for the saline group; n = 7 mice for the clozapine group).