Fig. 1.

Receiver Operating Characteristic (ROC) curve assessment of aAB biomarkers for detection of AD-related pathology in Testing Set subjects; cases (pre-symptomatic, prodromal, and mild-moderate AD) (n = 90) versus cognitively normal controls (n = 54) when used alone (green line), with age as an additional parameter (blue line) in a group with non-age-matched controls, and with age as an additional parameter with a more closely age-matched control group (red line). Results show that inclusion of age as an additional parameter significantly increases overall diagnostic accuracy and, thus, the overall utility of the test. The dashed line represents the line of no discrimination. The ROC area under the curve (AUC), sensitivity, specificity, PPV, NPV, and overall accuracy values are shown in Table 3.