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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Dev Biol. 2022 Dec 23;495:42–53. doi: 10.1016/j.ydbio.2022.11.010

Figure 6: HMGA2 Rescues Spemann Organizer Cell Fates in β-catenin Depleted Embryos.

Figure 6:

A) Overexpression of WT HMGA2 is sufficient to induce broad ectopic goosecoid expression in the animal pole of stage 10.5 embryos. Overexpression of S18D and S43D HMGA2 induces localized expression of goosecoid. 3 biological replicates. B) In β-catenin morphants, HMGA2 overexpression can rescue Spemann Organizer gene expression. Wild-type HMGA2 rescues goosecoid expression in a broad pattern on the animal pole, while S18D and S43D rescue in a more localized pattern 3 biological replicates. C) MINK1 overexpression cannot rescue Spemann Organizer gene expression in β-catenin morphants. 3 biological replicates.