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UNC6934 enables the development of NSD2-targeted degraders. (A) Domain architecture of the two main isoforms, NSD2-short (MMSET I) and NSD2-long (MMSET II). (B) UNC6934 (cyan) bound to NSD2-PWWP1 (magenta) (PDB: 6XCG). (C) Chemical structure of the NSD2-PWWP1 chemical probe, UNC6934. (D) Schematic of induced degradation of NSD2 via a heterobifunctional degrader. Created with BioRender.com.
