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. Author manuscript; available in PMC: 2023 Apr 20.
Published in final edited form as: Nat Microbiol. 2023 Mar 23;8(4):679–694. doi: 10.1038/s41564-023-01344-8

Extended Data Figure 5. Limited 3D genome changes in cells infected by HCoV-OC43, treated by HI-WA1 or poly(I:C).

Extended Data Figure 5.

a,b,c. Barplots showing the percentage of genomic bins (100kb bin size) that can be categorized into six groups based on their compartmental score changes (E1 values). These six categories are: A to weaker A, A to B, B to stronger B, B to weaker B, B to A, and A to stronger A. The a,b,c panels show the changes after treatments by poly (I:C), HI-WA1 and HCoV-OC43, respectively.

d-j. Venn diagrams showing the overlaps of genomic bins displaying E1 score alteration (i.e., compartmental changes) incurred by SARS-CoV-2 (pink) versus those by HCoV-OC43 (Cyan). Numbers indicate bins with changes belong to different categories: total changed bins (d), A to weaker A(e), A to B (f), B to stronger B (g), B to weaker B(h), B to A(i), A to stronger A(j).

k-l. Aggregated domain analyses (ADA) in cells treated by HI-WA1, poly(I:C) and HCoV-OC43, in comparison to their corresponding mock samples. HI-WA1 and HCoV-OC43 samples share the same Mock. In each figure, color scales indicate aggregated Hi-C contact frequencies (left and middle), and log2 fold change of SARS-CoV-2/Mock aggregated contact frequencies (right).