Table 4.
Clinical Characteristics and Severity of Moderate-to-Severe Diarrhea Children With Either the Single Diarrheagenic Escherichia coli (DEC) Pathotype Detected or the Single DEC Pathotype Coinfected With Another Enteric Pathogen
| Clinical Characteristic | EAEC Onlya n = 112 |
EAEC + Anya n = 2639 |
tEPEC Onlya n = 20 |
tEPEC + Anya n = 1023 |
aEPEC Onlya n = 27 |
aEPEC + Anya n = 1070 |
STEC Onlya n = 6 |
STEC + Anya n = 235 |
|---|---|---|---|---|---|---|---|---|
| Duration of diarrheal episode, median (Q1–Q3), d | 6 (4–8) | 5 (4–8) | 4 (3–6.25) | 5 (4–8) | 4 (2–6) | 5 (3–8) | 6.5 (4.5–8.5) | 5 (3–8) |
| Maximum number of stools per day on worst day | ||||||||
| ȃ3 | 37 (33.0%) | 630 (23.9%) | 5 (25.0%) | 272 (26.6%) | 9 (33.3%) | 250 (23.4%) | 2 (33.3%) | 56 (23.8%) |
| ȃ4–5 | 62 (55.4%) | 1556 (59.0%) | 10 (50.0%) | 590 (57.7%) | 14 (51.9%) | 641 (59.9%) | 4 (66.7%) | 136 (57.9%) |
| ȃ6–10 | 13 (11.6%) | 429 (16.3%) | 4 (20.0%) | 152 (14.9%) | 3 (11.1%) | 171 (16%) | 0 | 37 (15.7%) |
| ȃ>10 | 0 | 24 (0.9%) | 1 (5.0%) | 9 (0.9%) | 1 (3.7%) | 8 (0.7%) | 0 | 6 (2.6%) |
| Persistent diarrhea (>14 d) | 13 (11.6%) | 242 (9.2%) | 1 (5.0%) | 90 (8.8%) | 1 (3.7%) | 104 (9.7%) | 0 | 26 (11.1%) |
| Blood in stool | 8 (7.1%) | 422 (16.0%) | 1 (5.0%) | 162 (15.8%) | 2 (7.4%) | 176 (16.4%) | 0 | 47 (20%) |
| Maximum number of vomiting episodes on worst day | ||||||||
| ȃNone | 65 (58.0%) | 1415 (53.6%) | 11 (55.0%) | 560 (54.7%) | 15 (55.6%) | 594 (55.5%) | 5 (83.3%) | 131 (55.7%) |
| ȃ1 | 14 (12.5%) | 229 (8.7%) | 0 | 93 (9.1%) | 1 (3.7%) | 86 (8.0%) | 0 | 23 (9.8%) |
| ȃ2–4 | 27 (24.1%) | 847 (32.1%) | 7 (35.0%) | 313 (30.6%) | 8 (29.6%) | 339 (31.7%) | 0 | 69 (29.4%) |
| ȃ≥5 | 6 (5.4%) | 148 (5.6%) | 2 (10.0%) | 57 (5.6%) | 3 (11.1%) | 51 (4.8%) | 1 (16.7%) | 12 (5.1%) |
| Fever | 24 (21.4%) | 657 (24.9%) | 3 (15.0%) | 227 (22.2%) | 3 (11.1%) | 252 (23.6%) | 2 (33.3%) | 70 (29.8%) |
| Oral rehydration solution (given or prescribed) | 112 (100.0%) | 2569 (97.3%) | 20 (100.0%) | 987 (96.5%) | 27 (100.0%) | 1046 (97.8%) | 6 (100%) | 226 (96.2%) |
| Intravenous fluids (given or prescribed) | 4 (3.6%) | 186 (7.0%) | 3 (15.0%) | 70 (6.8%) | 3 (11.1%) | 72 (6.7%) | 0 | 15 (6.4%) |
| Hospitalized | 9 (8.0%) | 165 (6.3%) | 1 (5.0%) | 62 (6.1%) | 3 (11.1%) | 54 (5.0%) | 0 | 21 (8.9%) |
| Died | 0 | 30 (1.1%) | 0 | 12 (1.2%) | 0 | 6 (0.6%) | 0 | 2 (0.9%) |
Abbreviations: aEPEC, atypical enteropathogenic E. coli; EAEC, enteroaggregative E. coli; STEC, Shiga toxin–producing E. coli; tEPEC, typical enteropathogenic E. coli.
“Only” denotes children with moderate-to-severe diarrhea (MSD) who had only this pathogen detected using TaqMan Array Card system quantitative polymerase chain reaction (TAC qPCR). “Any” denotes children with MSD who had the diarrheagenic Escherichia coli pathogen and any of the following detected using TAC qPCR: adenovirus 40/41, Aeromonas spp., astrovirus, toxigenic Bacillus fragilis, Campylobacter spp., Cryptosporidium spp., Enterocytozoon bieneusi, Helicobacter pylori, norovirus GI, norovirus GII, Plesiomonas spp., rotavirus, Salmonella spp., sapovirus, Shigella spp./Enteroinvasive E. coli, heat stable– or heat labile–producing enterotoxigenic E. coli.