TABLE 3.
Efficacy of macrolide resistance prediction by MGIT-seq in comparison of drug susceptibility testsa
| Species (n = 103) | Genotype with rrl position at: |
Data for erm(41) |
Predicted macrolide susceptibility | No. (%) | Drug susceptibility test | No. (%) | ||
|---|---|---|---|---|---|---|---|---|
| 2058 | 2059 | State | Genotype at position 28 | |||||
| M. abscessus isolates (n = 8) | A | A | Complete | T | R | 3 (3.0) | R | 3 (3.0) |
| A | A | Truncated | T | S | 5 (4.9) | S | 5 (4.9) | |
| MAC isolates (n = 95) | A | A | None | S | 77 (74.7) | S | 75 (72.8) | |
| I | 1 (1.0) | |||||||
| R | 1 (1.0) | |||||||
| G | A | None | R | 3 (3.0) | R | 3 (3.0) | ||
| C | A | None | R | 6 (5.8) | R | 6 (5.8) | ||
| T | A | None | R | 2 (1.9) | R | 1 (1.0) | ||
| S | 1 (1.0) | |||||||
| A | G | None | R | 3 (3.0) | R | 2 (1.9) | ||
| S | 1 (1.0) | |||||||
| A | C | None | R | 4 (3.9) | R | 4 (3.9) | ||
a
MGIT-seq, direct sequence of positive mycobacterial growth indicator tube broth; MAC, Mycobacterium avium complex; R, resistant; I, intermediate; S, susceptible.