Table 11.
Initial cognitive diagnoses in clinicopathologically defined PSP and incidental PSP (iPSP)
| Clinically diagnosed PSP (n = 13) | Clinically undiagnosed PSP (n = 57) | Non-PSP (n = 686) | Total (n = 756) | p-Value | |
|---|---|---|---|---|---|
| First cognitive exam, n (%) | 0.023* | ||||
| NL | 3 (23.1%) | 31 (54.4%) | 382 (55.7%) | 416 (55.0%) | |
| MCI | 3 (23.1%) | 14 (24.6%) | 94 (13.7%) | 111 (14.7%) | |
| DEM | 7 (53.8%) | 12 (21.1%) | 210 (30.6%) | 229 (30.3%) | |
| Linked clinical and movement diagnosis group at first visit, n (%) | 0.021* | ||||
| Cog normal, no parkinsonism | 2 (15.4%) | 16 (28.1%) | 272 (39.7%) | 290 (38.4%) | |
| Cog normal, with parkinsonism | 1 (7.7%) | 15 (26.3%) | 110 (16.0%) | 126 (16.7%) | |
| Cog MCI or dementia, no parkinsonism | 2 (15.4%) | 11 (19.3%) | 138 (20.1%) | 151 (20.0%) | |
| Cog MCI or dementia, with parkinsonism | 8 (61.5%) | 15 (26.3%) | 166 (24.2%) | 189 (25.0%) | |
| Last cognitive exam, n (%) | 0.391* | ||||
| NL | 3 (23.1%) | 15 (26.3%) | 240 (35.0%) | 258 (34.1%) | |
| MCI | 1 (7.7%) | 11 (19.3%) | 119 (17.3%) | 131 (17.3%) | |
| DEM | 9 (69.2%) | 31 (54.4%) | 327 (47.7%) | 367 (48.5%) | |
| Linked clinical and movement diagnosis group at last visit, n (%) | <0.001* | ||||
| Cog normal, no parkinsonism | 0 (0.0%) | 5 (8.8%) | 183 (26.7%) | 188 (24.9%) | |
| Cog normal, with parkinsonism | 3 (23.1%) | 10 (17.5%) | 57 (8.3%) | 70 (9.3%) | |
| Cog MCI or dementia, no parkinsonism | 1 (7.7%) | 16 (28.1%) | 201 (29.3%) | 218 (28.8%) | |
| Cog MCI or dementia, with parkinsonism | 9 (69.2%) | 26 (45.6%) | 245 (35.7%) | 280 (37.0%) | |
Parkinsonism is defined as anyone who had movement diagnosis of suspected PD, possible PD, probable PD, parkinsonism NOS, PSP, DLB, MSA, and CBD.
*
Chi-Square p-value.