Table 6.

Accuracy of specific signs and symptoms for predicting clinicopathologically defined PSP

	Path PSP	Path non-PSP	Sensitivity	Specificity	PPV	NPV	Accuracy
UPDRS II fall score (any exam > 0)
Yes	54	296	64.3% (53.1%, 74.4%)		15.4%	94.7%	64.2%
No	30	531		64.2% (60.8%, 67.5%)
UPDRS II swallow score (any exam > 0)
Yes	49	318	57.6% (46.4%, 68.3%)		13.4%	93.4%	61.2%
No	36	510		61.6% (58.2%, 64.9%)
UPDRS II freeze score (any exam > 0)
Yes	24	171	28.6% (19.2%, 39.5%)		12.3%	91.6%	74.7%
No	60	657		79.3% (76.4%, 82.1%)
UPDRS III speech motor score (any exam > 0)
Yes	60	420	69.8% (58.9%, 79.2%)		12.5%	93.9%	50.7%
No	26	398		48.7% (45.2%, 52.1%)
UPDRS III facial expression score (any exam > 0)
Yes	63	443	73.3% (62.6%, 82.2%)		12.5%	94.2%	48.5%
No	23	375		45.8% (42.4%, 49.3%)
UPDRS III posture stability score (any exam > 0)
Yes	78	671	90.7% (82.5%, 95.9%)		10.4%	94.7%	24.6%
No	8	143		17.6% (15.0%, 20.4%)
Downgaze palsy
Yes	16	20	18.4% (10.9%, 28.1%)		44.4%	92.1%	90.2%
No	71	826		97.6% (96.4%, 98.6%)
Square wave jerks
Yes	13	14	14.9% (8.2%, 24.2%)		48.1%	91.8%	90.6%
No	74	833		98.3% (97.2%, 99.1%)
No RBD diagnosis
Yes	61	606	85.9% (75.6%, 93.0%)		9.1%	90.4%	20.1%
No	10	94		13.4% (11.0%, 16.2%)
Hoehn and Yahr stage ≥2.5*
Yes	58	364	66.7% (55.7%, 76.4%)		13.7%	94.2%	57.3%
No	29	469		56.3% (52.9%, 59.7%)

^*The cutoff was chosen based on Youden index.