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Predicting ANKRD11 protein tolerance to missense variants. The diagram on the top illustrates ANKRD11’s tolerance to missense changes landscape according to MetaDome web server. The protein structure is depicted on the bottom with ankyrin repeat domains shown. Missense variants analyzed in the present work are indicated in green. (A) Zoomed view for variants p.(Thr236Met) and p.(lys459Asn). (B) Zoomed view for p.(Ile2427Thr).
