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In vitro human PP model based on organ-on-a-chip technology. PPs-specific ECM, immune cells, epithelial cells, and signaling factors for the differentiation of M cells, and IgA-secreting B cells can be incorporated in the proposed PP system. The human PP model can offer a promising in vitro tool for studying infection and intestinal damage by chronic inflammation, and for discovering tissue regeneration strategy and therapeutics to control intestinal infection
