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. Author manuscript; available in PMC: 2023 Jul 11.
Published in final edited form as: Sci Transl Med. 2023 Jan 11;15(678):eadd8469. doi: 10.1126/scitranslmed.add8469

Figure 1. Antigen-complexed autoantibodies are highly upregulated in SCLC.

Figure 1.

(A) The mean coefficient signal of upregulated (p<0.05) IgG and IgM autoantibodies in SCLC are higher (one-way ANOVA) than any other cancer type analyzed on antibody-antigen complex arrays. n=98 SCLC and 125 controls; n=47 NSCLC and 47 controls; n=86 pancreatic cancer and 86 controls; n=139 colon cancer and 139 controls; n=121 breast cancers and 121 controls. Box and whisker plots indicate the range of coefficients min to max for each sample. (B to D) IgG and IgM autoantibodies were sequentially discovered in the Cardiovascular Health Study (CHS) pre-diagnostic cohort (B), tested in the Fred Hutch diagnostic cohort (C), and validated in a third cohort from Vanderbilt (D). Blue circles indicate increased IgG against the target Ag; red circles indicate increased IgM against the target Ag; - indicates decreased antibodies against the target Ag; and × indicates no significant difference.