Skip to main content
. Author manuscript; available in PMC: 2023 Jul 11.
Published in final edited form as: Sci Transl Med. 2023 Jan 11;15(678):eadd8469. doi: 10.1126/scitranslmed.add8469

Figure 4. SCLC AAb can target isoaspartylated post-translational modifications.

Figure 4.

(A) Shown are immunoblots from GST-fusion proteins bound to glutathione beads, treated with or without isoaspartylation-inducing buffer (IsoAsp), incubated with pooled plasma from patients with SCLC (n=5 cases) and probed with anti-human IgG and anti-GST antibodies. (B) Multiple immunoblot experiments were quantified (N=3 to 4). Data are presented as individual data points and the bar represents the mean ± SEM (C) The ratio of IgG from SCLC patient plasma bound to IsoAsp compared to wild type (WT) peptides was measured by ELISA (n=4 to 8 cases). Horizontal bars indicate the mean.