FIGURE 3.

Distribution of ER morphology proteins mapped onto eukaryotic phylogeny. The most likely point of origin of each protein is indicated, based on the results of the present study. The tree omits much detail regarding losses of paralogs from specific taxa and ignores any potential lateral gene transfer. STIM1: most likely origin, but with multiple secondary losses (also see Figure 2). Sey1p, synthetic enhancer of Yop1p; LECA, last eukaryotic common ancestor; STIM1, stromal interaction molecule 1, other abbreviations as in Figure 1.