Table 4.

Subpeak voxel locations where patients exhibited greater atrophy (i.e., lower cortical thickness) than healthy controls

Hemisphere	Region	T. statistic	X	Y	Z
bvAD versus Healthy Control
Left	Anterior cingulate gyrus	5.415	−2	47	22
	Gyrus rectus	5.408	−8	22	−22
	Middle frontal gyrus	5.241	−41	45	12
	Middle temporal gyrus	5.213	−62	−53	1
	Superior frontal gyrus	5.19	−22	59	7
	Amygdala	4.8	−29	−7	−17
	Anterior insula	4.756	−40	17	−3
	Superior frontal gyrus	4.67	−11	34	50
	Middle frontal gyrus	4.486	−41	16	43
	Middle temporal gyrus	4.453	−51	−5	−29
Right	Superior temporal gyrus	5.999	57	−37	11
	R anterior insula	5.915	41	−3	11
	R middle frontal gyrus	5.836	43	47	10
	R superior frontal gyrus	5.433	25	37	40
	R anterior insula	5.425	42	19	−2
	Angular gyrus	5.353	44	−57	28
	Cerebral White Matter	5.338	25	−6	−11
	R middle temporal gyrus	5.126	66	−19	−18
	R superior frontal gyrus	5.112	23	52	26
	Posterior orbital gyrus	5.074	34	36	−10
bvFTD versus Healthy Control
Left	Anterior insula	8.722	−35	23	−3
	Superior frontal gyrus medial segment	8.554	−8	49	22
	Middle frontal gyrus	8.129	−34	45	28
	Middle frontal gyrus	7.927	−41	46	9
	Amygdala	7.713	−27	−8	−12
	Anterior orbital gyrus	7.329	−19	63	−7
	Middle frontal gyrus	7.121	−36	21	47
	Entorhinal area	6.953	−26	−3	−34
	Superior frontal gyrus	6.867	−8	49	45
	Temporal pole	6.773	−36	22	−36
Right	Anterior insula	9.353	42	19	−2
	Middle frontal gyrus	9.09	43	47	10
	Posterior insula	9.088	44	−2	−2
	Posterior orbital gyrus	8.32	27	30	−20
	Amygdala	7.985	25	−6	−11
	Middle temporal gyrus	7.791	46	0	−31
	Middle temporal gyrus	7.777	64	−28	−1
	Middle frontal gyrus	7.774	44	37	28
	Superior frontal gyrus	7.476	25	60	23
	Temporal pole	7.375	23	17	−38
aAD versus Healthy Control
Left	Amygdala	6.286	25	10	−10
	Middle temporal gyrus	5.621	66	46	3
	Middle frontal gyrus	4.998	35	−47	23
	Precentral gyrus	4.873	45	−4	28
	Superior occipital gyrus	4.727	24	91	16
	Middle frontal gyrus	4.713	36	−21	47
	Posterior insula	4.468	29	27	16
	Angular gyrus	4.4	38	62	55
	Supramarginal gyrus	4.364	50	55	23
	Superior parietal lobule	4.276	30	41	48
Right	Middle frontal gyrus	4.743	−43	−47	10
	Amygdala	4.592	−27	8	−10
	Supramarginal gyrus	4.566	−48	42	52
	Postcentral gyrus	4.524	−66	17	22
	Angular gyrus	4.512	−54	55	26
	Posterior insula	4.425	−44	4	1
	Inferior occipital gyrus	4.277	−33	86	−4
	Posterior cingulate gyrus	4.255	−1	42	35
	Superior parietal lobule	4.184	−24	63	45
	Superior temporal gyrus	4.169	−64	36	10

Results are based on a statistical threshold of p < 0.05, after application of FSL’s threshold-free cluster enhancement algorithm and family-wise error correction for multiple comparisons. Top ten most significant subpeaks in both hemispheres are reported in MNI coordinates.