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. Author manuscript; available in PMC: 2023 Apr 20.
Published in final edited form as: Acc Mater Res. 2022 Mar 4;3(3):283–296. doi: 10.1021/accountsmr.1c00178

Figure 5.

Figure 5.

(A) Structural basis of the mitochondrion-targeting properties of cisplatin prodrugs and polymeric nanoparticles, allowing for improved delivery of drugs to mitochondria and the targeting of mitochondrial DNA. (B) Ability of mitochondrion-targeted nanoparticles to accumulate in the mitochondrial matrix. (C) Demonstration of cisplatin delivery to the mitochondria in the form of a prodrug and a nanoparticle and the formation of mitochondrial DNA adducts. Adapted with permission from refs 42 and 43. Copyright 2012 and 2014 National Academy of Sciences.