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Mechanism of spermidine-induced autophagy. Abbreviations: FOXO: Fork-head transcription factors of the O class; Akt, Ak strain transforming; BNIP3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Ac, acylated; P, phosphorylated; HAT, histone acetyltransferase; EP300, E1A-associated protein p300; αtat1, α-tubulin acetyltransferase; CTSL, cathepsin L; ATG, autophagy related gene.
