Figure 6.

Treatment of staphylococcal biofilms established on catheter sections. Biofilms were grown on 1.5 cm polyurethane catheters for 24 h in vitro then treated with either vancomycin (5 mg/mL) or vB_SepM_BE04 (∼10⁹ plaque forming units/ml). Viable colony forming units (CFU) where determined on agar plates following treatment. Data were compared using two-way ANOVA (treatment effect P < 0.0001; strain effect P< 0.0001; interaction P = 0.896). Simple pairwise comparisons between treatments are shown, and significant differences are illustrated using asterisks (*P < 0.05i>; **P< 0.01i>; ***P< 0.001; ^****P< 0.0001). The black dotted line represents the limit of detection (1 log₁₀CFU/mL). MRSE, methicillin-resistant S. epidermidis; MSSE, methicillin-sensitive S. epidermidis.