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. 2022 Jul 25;3:xtac022. doi: 10.1093/femsmc/xtac022

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© The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — IAV–Sp coinfection kinetics. Viral titers, bacterial titers, and alveolar macrophages (AMΦ) during IAV infection (75 TCID₅₀ PR8; black squares) or IAV–Sp coinfection (colored circles), where animals were infected with 75 TCID₅₀ PR8 followed by 10³ CFU D39 at 3 d (A; magenta), 5 d (B; green), or 7 d (C; blue) pvi. Data are shown for five individual animals with virus, bacteria, and AMΦ simultaneously measured. Dynamics of the model in Equations (1–8) are shown (solid line) for each scenario, and two trajectories with differing values of K_M = 7.5e5 (solid) or 4e5 (dashed) are shown for a coinfection at 3 d pvi. (D) Percentage of weight following IAV infection (black squares) or IAV–Sp coinfection (colored circles). Time indicates time postinfluenza infection.