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. 2022 Jun 30;3:uqac009. doi: 10.1093/femsml/uqac009

Table 1.

Differential abundance of cell wall-modifying enzymes in cells and MVs of P. aeruginosa PAO1 upon MMC treatment. Predicted localization of proteins: C, cytoplasm; IM, inner membrane associated; P, periplasm; OM, outer membrane associated; E, extracellular.

Gene number Gene name Protein description Size (kDa) Possible localization Fold increase
Cells MVs
PA0378 mtgA Biosynthetic peptidoglycan transglycosylase 26.5 IM < 2.0 11.2
PA0629 lys Endolysin 23.0 P 27.4 2.1
PA0807 ampDh3 AmpDh3 28.7 P 98.0 2.9
PA0869 pbpG (PBP7) D-alanyl-D-alanine endopeptidase 34.0 P 30.5 < 2.0
PA1171 sltB2 (sltG) Soluble lytic transglycolase 42.7 IM 6.8 3.7
PA1222 mltA Membrane-bound lytic murein transglycosylase A 41.9 OM 5.9 20.4
PA2854 erfK Putative L,D-transpeptidase 34.8 P 2.5 < 2.0
PA2963 mltG Endolytic murein transglycosylase 39.6 IM < 2.0 5.5
PA3020 mltC Probable soluble lytic transglycosylase 73.4 P 5.7 < 2.0
PA3047 dacB (PBP4) Probable D-alanyl-D-alanine carboxypeptidase 51.9 P < 2.0 14.1
PA3484 tse3 Muramidase (toxin of Type VI secretion system) 44.4 E 11.6 < 2.0
PA3764 mltF Membrane-bound lytic murein transglycosylase F 55.2 OM 3.0 26.6
PA3992 sltB3 (sltH) Soluble lytic (exolytic) transglycosylase 47.8 IM 3.1 3.7
PA4000 rlpA Endolytic peptidoglycan transglycosylase RlpA 36.5 IM < 2.0 7.0
PA4001 sltB1 Soluble lytic transglycosylase B 37.9 IM < 2.0 16.1
PA4003 pbpA Peptidoglycan D,D-transpeptidase MrdA 72.2 IM 6.8 17.6
PA4412 murG UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 37.8 IM < 2.0 5.1
PA4413 ftsW Probable peptidoglycan glycosyltransferase FtsW 43.8 IM < 2.0 2.3
PA4414 murD UDP-N-acetylmuramoylalanine–D-glutamate ligase 48.1 C 2.3 < 2.0
PA4417 murE UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase 51.3 C < 2.0 4.2
PA4418 ftsI (PBP3) Peptidoglycan D,D-transpeptidase FtsI 62.9 IM 59.4 5.5
PA4450 murA UDP-N-acetylglucosamine-1-carboxyvinyltransferase 44.6    C    2.5   <2.0
PA4700 mrcB (PBP1b) Penicillin-binding protein 1B 85.5 IM 7.7 3.6
PA4749 glmM Phosphoglucosamine mutase 47.8 C 4.2 < 2.0
PA4947 amiB N-acetylmuramoyl-L-alanine amidase 50.7 OM 3.9 < 2.0
PA5045 mrcA (PBP1a) Penicillin-binding protein 1A 91.2 IM 3.0 6.0
PA5485 ampDh2 AmpDh2 28.9 OM 4.1 7.0