Abstract
Popliteal lymph nodes from eight New Zealand white rabbits with clinical or serological evidence of naturally acquired infection with Treponema paraluis-cuniculi were transferred to rabbits that had not been exposed to this infection. Lymph nodes from two rabbits successfully transmitted infection. The nodes from one of these rabbits transmitted infection during both the acute and chronic stages of infection. Recipients that were successfully infected showed concomitant antibody responses in the Venereal Disease Research Laboratory (VDRL), rapid plasma reagin (RPR), and fluorescent treponemal antibody-absorption (FTA-ABS) tests six to 10 weeks after inoculation; recipients of uninfected nodes showed no change in serological state. Antibody responses were followed by the development of dark field positive genital lesions 14 to 15 weeks after inoculation.
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Selected References
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- Clark J. W., Jr Serological tests for syphilis in healthy rabbits. Br J Vener Dis. 1970 Jun;46(3):191–197. doi: 10.1136/sti.46.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Collart P., Franceschini P., Durel P. Experimental rabbit syphilis. Br J Vener Dis. 1971 Dec;47(6):389–400. doi: 10.1136/sti.47.6.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cunliffe-Beamer T. L., Fox R. R. Venereal spirochetosis of rabbits: epizootiology. Lab Anim Sci. 1981 Aug;31(4):372–378. [PubMed] [Google Scholar]
- DiGiacomo R. F., Talburt C. D., Lukehart S. A., Baker-Zander S. A., Condon J. Treponema paraluis-cuniculi infection in a commercial rabbitry: epidemiology and serodiagnosis. Lab Anim Sci. 1983 Dec;33(6):562–566. [PubMed] [Google Scholar]
- Graves S. R., Edmonds J. W., Shepherd R. C. Lack of serological evidence for venereal spirochaetosis in wild Victorian rabbits and the susceptibility of laboratory rabbits to Treponema paraluis-cuniculi. Br J Vener Dis. 1980 Dec;56(6):381–386. doi: 10.1136/sti.56.6.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODESSON S., MILLER J. N. TESTIS AND POPLITEAL LYMPH NODE REMOVAL FROM THE LIVING RABBIT USING ASEPTIC TECHNIQUES AND ETHER ANESTHESIA. Lab Anim Care. 1964 Dec;14:494–498. [PubMed] [Google Scholar]
- Levine B. M., Smith J. L., Martinez S. A., Montenegro E. N., Nicol W. G. VDRL test in normal albino and pigmented rabbits. Br J Vener Dis. 1969 Sep;45(3):197–199. doi: 10.1136/sti.45.3.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lukehart S. A., Baker-Zander S. A., Lloyd R. M., Sell S. Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions. J Immunol. 1980 Jan;124(1):461–467. [PubMed] [Google Scholar]
- Lukehart S. A., Baker-Zander S. A., Lloyd R. M., Sell S. Effect of cortisone administration on host-parasite relationships in early experimental syphilis. J Immunol. 1981 Oct;127(4):1361–1368. [PubMed] [Google Scholar]
- Lukehart S. A., Baker-Zander S. A., Sell S. Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens. J Immunol. 1980 Jan;124(1):454–460. [PubMed] [Google Scholar]
- MILLER J. N. THE APPEARANCE AND PERSISTENCE OF VDRL, RPCF, AND TPI ANTIBODY DURING THE COURSE AND TREATMENT OF EXPERIMENTAL SYPHILIS IN THE RABBIT. J Invest Dermatol. 1964 May;42:367–371. doi: 10.1038/jid.1964.80. [DOI] [PubMed] [Google Scholar]
- Pannu J. S., Rosenberg M. A., Israel C. W., Smith J. L. Incidence of reactive VDRL tests in the normal rabbit. Br J Vener Dis. 1967 Jun;43(2):114–116. doi: 10.1136/sti.43.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Small J. D., Newman B. Venereal spirochetosis of rabbits (rabbit syphilis) due to Treponema cuniculi: a clinical, serological, and histopathological study. Lab Anim Sci. 1972 Feb;22(1):77–89. [PubMed] [Google Scholar]
- Smith J. L., Pesetsky B. R. The current status of treponema cuniculi. Review of the literature. Br J Vener Dis. 1967 Jun;43(2):117–127. doi: 10.1136/sti.43.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tight R. R., Leland D., French M. L. Incidence of positive serologic tests for treponemal infection in healthy rabbits. Sex Transm Dis. 1981 Jan-Mar;8(1):8–11. doi: 10.1097/00007435-198101000-00003. [DOI] [PubMed] [Google Scholar]
- Tight R. R., White A. C. Quantitative microhaemagglutination assay for Treponema pallidum antibodies in experimental syphilis. Br J Vener Dis. 1980 Oct;56(5):291–296. doi: 10.1136/sti.56.5.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Turner T. B., Hardy P. H., Newman B. Infectivity tests in syphilis. Br J Vener Dis. 1969 Sep;45(3):183–195. doi: 10.1136/sti.45.3.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yobs A. R., Clark J. W., Jr, Mothershed S. E., Bullard J. C., Artley C. W. Further observations on the persistence of Treponema pallidum after treatment in rabbits and humans. Br J Vener Dis. 1968 Jun;44(2):116–130. doi: 10.1136/sti.44.2.116. [DOI] [PMC free article] [PubMed] [Google Scholar]