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. 2023 Apr 6;14:1138162. doi: 10.3389/fphys.2023.1138162

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Copyright © 2023 Meng, Geng, Jin, Teng, Xiao, Wu and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endothelial senescence promotes aging-related CVD. Senescent ECs which are occurred during aging process or caused by ROS, chronic low-grade sterile inflammation, L5, excessive calorie and Ras are reported to possess prothrombotic, pro-oxidant, pro-inflammatory, and vasoconstrictor properties. Senescent ECs promote the occurrence of coronary heart disease, systemic metabolism disorder and diabetes mellitus. Senescent ECs exhibit increased NOX2, ICAM-2, VEGFA₁₆₅b, p53, p21, p16, CCL19, CCL21, IL-1β, IL-6, IL-18, and TNF-α. Meanwhile, decreased eNOS and PGC1-α are observed in senescent ECs.